PF-543 HCl | Sphingosine kinase-1 inhibitor
Available Options
| Size | Price | Quantity | |
|---|---|---|---|
| 5mg | $75.00 | ||
| 25mg | $270.00 |
PF-543 (1706522-79-3) is a potent (IC50 = 2.0 nM) and selective (>100-fold over SphK2) reversible inhibitor of sphingosine kinase-1 (SphK1).1 It induced autophagy in head and neck squamous cell carcinoma cells.2 PF-543 mitigated pulmonary fibrosis via reducing lung epithelial cell mitochondrial DNA damage and monocyte recruitment.3 It also alleviated sepsis-induced lung injury in an acute ethanol intoxication model in mice.4 PF-543 inhibited cell cycle and tumor growth in a xenograft model of non-small cell lung cancer.5
References/Citations:
- Schnute et al. (2012), Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1; Biochem. J. 444 79
- Hamada et al. (2017); Induction of autophagy by sphingosine kinase 1 inhibitor PF-543 in head and neck squamous cell carcinoma cells, Cell Death Discov. 3 17047
- Cheresh et al. (2020); The Sphingosine Kinase 1 Inhibitor, PF543, Mitigates Pulmonary Fibrosis by Reducing Lung Epithelial Cell mtDNA Damage and Recruitment of Fibrogenic Monocytes, Int. J. Mol. Sci. 21 5595
- Chen et al. (2021); Blocking SphK1/S1P/S1PR1 Signaling Pathway Alleviates Lung Injury Caused by Sepsis in Acute Ethanol Intoxication in Mice, Inflammation 44 2170
- Lin et al. (2022); Targeting SPHK1/PBX1 Axis Induced Cell Cycle Arrest in Non-Small Cell Lung Cancer, Int. J. Mol. Sci. 23 12741
C27H31NO4S·HCl
>98% HPLC
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
PF-543 (1706522-79-3) is a potent (IC50 = 2.0 nM) and selective (>100-fold over SphK2) reversible inhibitor of sphingosine kinase-1 (SphK1).1 It induced autophagy in head and neck squamous cell carcinoma cells.2 PF-543 mitigated pulmonary fibrosis via reducing lung epithelial cell mitochondrial DNA damage and monocyte recruitment.3 It also alleviated sepsis-induced lung injury in an acute ethanol intoxication model in mice.4 PF-543 inhibited cell cycle and tumor growth in a xenograft model of non-small cell lung cancer.5
References/Citations:
- Schnute et al. (2012), Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1; Biochem. J. 444 79
- Hamada et al. (2017); Induction of autophagy by sphingosine kinase 1 inhibitor PF-543 in head and neck squamous cell carcinoma cells, Cell Death Discov. 3 17047
- Cheresh et al. (2020); The Sphingosine Kinase 1 Inhibitor, PF543, Mitigates Pulmonary Fibrosis by Reducing Lung Epithelial Cell mtDNA Damage and Recruitment of Fibrogenic Monocytes, Int. J. Mol. Sci. 21 5595
- Chen et al. (2021); Blocking SphK1/S1P/S1PR1 Signaling Pathway Alleviates Lung Injury Caused by Sepsis in Acute Ethanol Intoxication in Mice, Inflammation 44 2170
- Lin et al. (2022); Targeting SPHK1/PBX1 Axis Induced Cell Cycle Arrest in Non-Small Cell Lung Cancer, Int. J. Mol. Sci. 23 12741
Related products
-
SNS-314 mesylate | Aurora kinase inhibitor
From $70.00CAS:1146618-41-8Catalog Number:10-4779Activity:Aurora kinase inhibitorChemical Name:1-(3-Chlorophenyl)-3-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-1,3-thiazol-2-yl]urea mesylateMolecular Weight:527.04Molecular Formula:C18H15ClN6OS2 • CH3SO3HSolubility:Soluble in DMSO (up to at least 25 mg/ml).Physical Properties:Off-white solidPurity:98% by HPLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.Shipping Code:RT -
HPI-1 | Hedgehog pathway inhibitor
From $75.00CAS:599150-20-6 (anhydrous)Catalog Number:10-4522Activity:Hedgehog pathway inhibitorChemical Name:2-Methoxyethyl 1,4,5,6,7,8-hexahydro-4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-3-quinolinecarboxylateMolecular Weight:463.52 (anhydrous)Molecular Formula:C27H29NO6 xH20Solubility:Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).Physical Properties:Yellow solidPurity:>98% by TLC
NMR (conforms)Storage Temperature:-20°Stability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.Shipping Code:RT -
N-Eicosanoyl serotonin | Neuroprotective
From $50.00Catalog Number:10-3631Activity:NeuroprotectiveChemical Name:Eicosanoyl-5-hydroxytryptamideAlternate Name:Eicosanoyl serotonin, EHTMolecular Weight:470.73Molecular Formula:C30H50N2O2Solubility:Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 20 mg/ml with warming)Physical Properties:Beige solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 2 years from date of purchase supplied. Protect from air. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21
Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21
Website Created by Advanta Advertising LLC.