Streptonigrin | Induces heterochromatin formation
NMR (Conforms)
Streptonigrin (3930-19-6) promotes heterochromatin formation at concentrations as low as 1 nM, a concentration at which there was no effect on proliferation or viability.1 Inhibits the SUMO-specific protease SENP1 resulting in increased global SUMOylation levels and reduced level of HIF1α.2 Stabilizes p53 via inhibition of transglutaminase 2 resulting in p53-mediated apoptosis in renal cell carcinoma cells.3 Cytotoxic to fast-cycling melanoma cells but leaves a small population of slow-dividing cells unaffected and may be considered a tool to enrich cultures with cells exhibiting melanoma stem cell characteristics.4
References/Citations:
- Loyola et al. (2020), Streptonigrin at low concentrations promotes heterochromatin formation; Sci. Rep. 10 3478
- Ambaye et al. (2018), Streptonigrin Inhibits SENP1 and Reduces the Protein Level of Hypoxia-Inducible Factor 1α (HIF1α) in Cells; Biochemistry 57 1807
- Lee et al. (2018), Renal Cell Carcinoma is Abrogated by p53 Stabilization through Transglutaminase 2 Inhibition; Cancers (Basel) 10 455
- Sztiller-Sikorska et al. (2014), Natural compounds’ activity against cancer stem0like or fast-cycling melanoma cells; PLoS One 9 e90783
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Streptonigrin (3930-19-6) promotes heterochromatin formation at concentrations as low as 1 nM, a concentration at which there was no effect on proliferation or viability.1 Inhibits the SUMO-specific protease SENP1 resulting in increased global SUMOylation levels and reduced level of HIF1α.2 Stabilizes p53 via inhibition of transglutaminase 2 resulting in p53-mediated apoptosis in renal cell carcinoma cells.3 Cytotoxic to fast-cycling melanoma cells but leaves a small population of slow-dividing cells unaffected and may be considered a tool to enrich cultures with cells exhibiting melanoma stem cell characteristics.4
References/Citations:
- Loyola et al. (2020), Streptonigrin at low concentrations promotes heterochromatin formation; Sci. Rep. 10 3478
- Ambaye et al. (2018), Streptonigrin Inhibits SENP1 and Reduces the Protein Level of Hypoxia-Inducible Factor 1α (HIF1α) in Cells; Biochemistry 57 1807
- Lee et al. (2018), Renal Cell Carcinoma is Abrogated by p53 Stabilization through Transglutaminase 2 Inhibition; Cancers (Basel) 10 455
- Sztiller-Sikorska et al. (2014), Natural compounds’ activity against cancer stem0like or fast-cycling melanoma cells; PLoS One 9 e90783
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Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21
Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21
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