WP631 | SP-1 activated transcription inhibitor

WP631 is a novel bisintercalating anthracycline. Potent inhibitor of Sp1-activated transcription.1,2 Induces caspase-dependent apoptosis in human ovarian cancer cells.3 Synergizes with epothilone at induction of apoptosis in human ovarian cancer cells.4  Abrogates HIV-1 replication via inhibition of Tat transactivation.5

References:

  1. Martin et al. (1999), Bisanthracycline WP631 inhibits basal and Sp-1-activated transcription initiation in vitro; Nucleic Acids Res,, 27 3402
  2. Mansilla et al. (2004), Sp1-targeted inhibition of gene transcription by WP631 in transfected lymphocytes; Biochemistry, 43 7584
  3. Gajek et al. (2014), Pro-apoptotic activity of new analog of anthracyclines—WP 631 in advanced ovarian cancer cell line; In Vitro, 28 273
  4. Bukowska et al. (2016), New Potential chemotherapy for ovarian cancer – Combined therapy with WP 631 and epothilone B; Life Sci., 151 86
  5. Kutsch et al. (2004), Bis-anthracycline antibiotics inhibit human immunodeficiency virus type 1 transcription; Agents Chemother., 43 1652
Weight 0.1 mg
Dimensions 0.1 × 0.1 × 0.1 cm
Size:

100 µg, 500 µg

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CAS:

Not available

Catalog Number:
10-3497
Activity:
SP-1 activated transcription inhibitor
Chemical Names:

4-Methylbenzyl-N-bis[daunomycin], mesylate salt

Molecular Weight:
1349.38
Molecular Formula:
C62H64N2O20 ∙ 2CH3SO3H
Solubility:
Soluble in DMSO (up to 5 mg/ml)
Physical Properties:
Red solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des,)
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

WP631 | SP-1 activated transcription inhibitor

$65.00$270.00

CAS:

Not available

Catalog Number:
10-3497
Activity:
SP-1 activated transcription inhibitor
Chemical Names:

4-Methylbenzyl-N-bis[daunomycin], mesylate salt

Molecular Weight:
1349.38
Molecular Formula:
C62H64N2O20 ∙ 2CH3SO3H
Solubility:
Soluble in DMSO (up to 5 mg/ml)
Physical Properties:
Red solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des,)
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
  • 100 µg
  • 500 µg
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