Two recent papers employed Sinefungin in determination of the structure of two different viral methyltransferases. Sinefungin is a Streptomyces natural product analog of S-adenosylmethionine acting as
In a molecular docking analysis, Tronco Pauletto et al. found that antidepressants such as fluoxetine, citalopram, and norfluoxetine likely interact with and disrupt SARS-CoV-2 main protease
Carlos Guijas and coworkers at Scripps recently found that the leukotriene antagonist and antiasthmatic agent zafirlukast was able to differentiate adipocyte precursors into functional brown adipocytes.
Yuki Yoshimatsu and coworkers have shown that they could establish patient-derived cancer cell lines for myxofibrosarcoma and pleomorphic sarcoma. After screening these cell lines with a
P. Hiengrach and coworkers recently showed that BAM15, a mitochondrial uncoupling agent, attenuated sepsis in a mouse cecal ligation and puncture model. BAM15 attenuated sepsis as
Activation of autophagy is a novel mode of therapeutic intervention and offers the possibility of developing new “host-directed” therapeutics against mycobacterial infection. For example, Kim et
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