Focus on Natural Products: Celebrating the birthday of Satoshi Omura (July 12). Omura is well known for his work on the isolation and structure identification of
Drug Approval News: Johnson & Johnson (J&J) has received approvals from both the European Commission (EC) and US Food and Drug Administration (FDA) for its tuberculosis
Natural Product Cellular Probes. Ascochlorin is a novel isoprenoid isolated from Acremonium egyptiacum. It is a specific inhibitor of the mitochondrial cytochrome bc1 complex (mitochondrial respiratory
Natural Product-Inspired Drugs. Camptothecin, an alkaloid isolated from Camptotheca acuminata, is a potent inhibitor of DNA topoisomerase I. Numerous useful analogs of camptothecin have been synthesized:
Focus on Natural Products: Microcystin LR, a cyanobacterial toxin that inhibits protein phosphatase 2A, was recently shown to stimulate tumor-associated macrophages to adopt an anti-tumor M1
On World Microbiome Day (June 27, 2024) we focus on gut microbial metabolites. Phenylacetyl-L-glutamine (PAGln) was shown to be a cardiovascular disease-linked gut microbial metabolite acting
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