P. Hiengrach and coworkers recently showed that BAM15, a mitochondrial uncoupling agent, attenuated sepsis in a mouse cecal ligation and puncture model. BAM15 attenuated sepsis as
Activation of autophagy is a novel mode of therapeutic intervention and offers the possibility of developing new “host-directed” therapeutics against mycobacterial infection. For example, Kim et
Paula Juricic and coworkers at the Max Planck Institute for Biology of Ageing report in a recent issue of Nature Aging that a brief early treatment
Robert Prior and coworkers report in a recent issue of Molecular Neurobiology that inhibition of HDAC3 with RGFP966, a highly selective HDAC3 inhibitor, stimulates myelination in
JM Snyder and coworkers report in the August issue of Geroscience that canagliflozin, a clinically important anti-diabetic agent, results in a 14% increase in median lifespan
Chroman 1 is an important new small molecule tool for the generation and maintenance of stem cells. An extremely potent (1 pM) inhibitor of Rho kinase
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