In a recent paper in Nature, Bryan Roth et al. revealed detailed features in the recognition of DREADD actuators by designer receptors. Muscarinic DREADDs or designer
Urolithin A is a microbial metabolite of dietary ellagitannins produced in the gut. It has been shown to induce mitophagy and prolong lifespan in C. elegans
Focus will be exhibiting at ASCB Cell Biology, Dec 3-7 in Washington DC. Stop by our booth #2205 and chat with our scientists! Learn about our
Filipin III is a microbial natural product isolated from Streptomyces filipinensis. It is an important fluorescent probe for cellular cholesterol detection. In addition, because it binds
Two recent papers employed Sinefungin in determination of the structure of two different viral methyltransferases. Sinefungin is a Streptomyces natural product analog of S-adenosylmethionine acting as
In a molecular docking analysis, Tronco Pauletto et al. found that antidepressants such as fluoxetine, citalopram, and norfluoxetine likely interact with and disrupt SARS-CoV-2 main protease
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