Focus on Natural Products: Microcystin LR, a cyanobacterial toxin that inhibits protein phosphatase 2A, was recently shown to stimulate tumor-associated macrophages to adopt an anti-tumor M1
On World Microbiome Day (June 27, 2024) we focus on gut microbial metabolites. Phenylacetyl-L-glutamine (PAGln) was shown to be a cardiovascular disease-linked gut microbial metabolite acting
Focus on Bioactive Natural Products: Verrucarin A, a structurally intriguing natural product produced by soil microbe Myrothecium spp. was shown by Kondo et al. to attenuate
Focus on Bioactive Natural Products: Just out in ACS Chemical Biology, FA Gowans and coworkers at Berkeley reported that ophiobolin A (OPA) covalently targets mitochondrial complex
Beauvericin, a mycotoxin produced by various Fusarium spp, is an important food and animal feed contaminant. Its diverse toxic activities coupled with its ability to cross
An interesting review has just been published in the May 23 issue of Cell by A Suomalainen and J Nunnari entitled “Mitochondria at the Crossroads of
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