Natural Product Cellular Probes. Ascochlorin is a novel isoprenoid isolated from Acremonium egyptiacum. It is a specific inhibitor of the mitochondrial cytochrome bc1 complex (mitochondrial respiratory
Natural Product-Inspired Drugs. Camptothecin, an alkaloid isolated from Camptotheca acuminata, is a potent inhibitor of DNA topoisomerase I. Numerous useful analogs of camptothecin have been synthesized:
Focus on Natural Products: Microcystin LR, a cyanobacterial toxin that inhibits protein phosphatase 2A, was recently shown to stimulate tumor-associated macrophages to adopt an anti-tumor M1
On World Microbiome Day (June 27, 2024) we focus on gut microbial metabolites. Phenylacetyl-L-glutamine (PAGln) was shown to be a cardiovascular disease-linked gut microbial metabolite acting
Focus on Bioactive Natural Products: Verrucarin A, a structurally intriguing natural product produced by soil microbe Myrothecium spp. was shown by Kondo et al. to attenuate
Focus on Bioactive Natural Products: Just out in ACS Chemical Biology, FA Gowans and coworkers at Berkeley reported that ophiobolin A (OPA) covalently targets mitochondrial complex
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