New Product Focus: Chroman 1 is an important new small molecule tool for the generation and maintenance of stem cells. An extremely potent (1 pM) inhibitor
Journal Club: Surfactin is a cyclic lipopeptide microbial metabolite produced by Bacillus subtilis that acts as a biosurfactant among other interesting activities. S.C. Yang and coworkers
In The News: Bempedoic acid is an FDA-approved drug for the treatment of hypercholesterolemia sold under the brand name Nexletol. It is an ATP citrate lyase
Focus on Drug Discovery: Saridegib is a natural product-inspired drug candidate. Its prototype, cyclopamine was discovered as a teratogenic steroidal alkaloid that was found to cause
Journal Club: Hutchinson-Gilford progeria syndrome (HGPS) is a rare premature aging disorder caused by the expression of progerin, a Lamin A mutant. The study of HGPS
Journal Club: In a paper just out in PNAS, Y. Lin and coworkers showed that Eltrombopag, an FDA-approved drug for thrombocytopenia, inhibits autophagy by targeting the
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