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Product Details

Niclosamide | STAT3 signaling inhibitor

Niclosamide (50-65-7) reversibly inhibits mTORC1 signaling and stimulates autophagy1. Inhibits activation and nuclear translocation of STAT3 selectively over STAT1 and STAT5. Niclosamide inhibits transcription of STAT3 target genes and induces cell cycle arrest and apoptosis in cells with constitutively active STAT32.

References/Citations
1) Balgi et al. (2009), Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling; PloS One, 4 e7124
2) Ren et al. (2010), Identification of Niclosamide as a New Small-Molecule Inhibitor of the STAT3 Signaling Pathway; ACS Med. Chem. Lett., 1 454

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Catalog#  10-2474

$28.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
50-65-7
Catalog Number:
10-2474
Activity:
STAT3 signaling inhibitor
Chemical Name:
5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
Molecular Weight:
327.13
Molecular Formula:
C13H8Cl2N2O4
Solubility:
Soluble in DMSO (up to 3 mg/ml), or in Ethanol (up to 6 mg/ml).
Physical Properties:
Yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 3 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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