Niclosamide | STAT3 signaling inhibitor
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 1 gram | $28.00 | ||
| 5 gram | $84.00 |
Niclosamide (50-65-7) reversibly inhibits mTORC1 signaling and stimulates autophagy.1 Inhibits activation and nuclear translocation of STAT3 selectively over STAT1 and STAT5. Niclosamide inhibits transcription of STAT3 target genes and induces cell cycle arrest and apoptosis in cells with constitutively active STAT3.2
References/Citations:
1) Balgi et al. (2009), Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling; PloS One, 4 e7124
2) Ren et al. (2010), Identification of Niclosamide as a New Small-Molecule Inhibitor of the STAT3 Signaling Pathway; ACS Med. Chem. Lett., 1 454
NMR (Conforms)
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Product Data Sheet:
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Niclosamide (50-65-7) reversibly inhibits mTORC1 signaling and stimulates autophagy.1 Inhibits activation and nuclear translocation of STAT3 selectively over STAT1 and STAT5. Niclosamide inhibits transcription of STAT3 target genes and induces cell cycle arrest and apoptosis in cells with constitutively active STAT3.2
References/Citations:
1) Balgi et al. (2009), Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling; PloS One, 4 e7124
2) Ren et al. (2010), Identification of Niclosamide as a New Small-Molecule Inhibitor of the STAT3 Signaling Pathway; ACS Med. Chem. Lett., 1 454
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Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21
Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21
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