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Product Details

Niguldipine HCl | L-type Ca channel blocker

Niguldipine HCl (113317-61-6) is an L-type calcium channel blocker (IC50 = 75 nM), which can also inhibit T-type calcium channels at higher concentrations (IC50 = 244 nM). Novel inhibitor of drug transport by p-glycoprotein.

References/Citations
1) Stengel et al. (1998), Different potencies of dihydropyridine derivatives in blocking T-type but not L-type Ca2+ channels in neuroblastoma-glioma hybrid cells; Eur. J. Pharmacol., 342 339
2) Hollt et al. (1992), Stereoisomers of calcium antagonists which differ markedly in their potencies as calcium blockers are equally effective in modulating drug transport by P-glycoprotein; Biochem. Pharmacol., 43 2601

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Niguldipine HCl | 113317-61-6 | Structure | Supplier

Catalog#  10-1215

$64.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
113317-61-6
Catalog Number:
10-1215
Activity:
L-type Ca channel blocker
Molecular Weight:
646.18
Molecular Formula:
C36H39N3O6 HCl
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Methanol (up to 25 mg/ml).
Physical Properties:
White solid
Purity:
98%
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year as supplied. Solutions in DMSO or methanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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