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Product Details

Nilotinib | BCR-ABL inhibitor

A novel, selective BCR-ABL inhibitor.  More potent than imatinib against wild-type BCR-ABL (IC50 < 30 nM)1. Induces apoptosis2.

References/Citations

1) Weisberg et al. (2006), AMN107 (nilotinib): a novel and selective inhibitor of BCR-ABL; Br J. Cancer, 94 1765
2) Verstovsek et al. (2006), Activity of AMN107, a novel aminopyrimidine tyrosine kinase inhibitor, against human FIP1L1-PDGFR-alpha-expressing cells; Ann. Neurol., 75 209

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Catalog#  10-2152

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CAS:
641571-10-0
Catalog Number:
10-2152
Activity:
BCR-ABL inhibitor
Chemical Name:
4-Methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzamide
Alternate Names:
AMN-107
Molecular Weight:
529.52
Molecular Formula:
C28H22F3N7O
Solubility:
Soluble in DMSO (up to 50 mg/ml)
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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