NKY-80 | Adenylate cyclase inhibitor
NMR (Conforms)
Available Options
| size : | Price | Quantity | |
|---|---|---|---|
| 5 mg | $58.00 | ||
| 25 mg | $232.00 |
NKY-80 (299442-43-6) is a potent and selective adenylyl cyclase inhibitor. Selective for AC5 and over AC3 and AC2 (IC50 = 8.3 μM, 132 μM and 1.7 mM respectively).1,2 More recently shown to indiscriminately inhibit AC6.3 NKY-80 is an extremely useful tool for probing the involvement of adenylyl cyclases in cellular signaling.4
References/Citations:
1) Onda et al. (2001), Type-specific regulation of adenylyl cyclase. Selective pharmacological stimulation and inhibition of adenylyl cyclase isoforms; J. Biol. Chem., 276 47785
2) Pierre et al. (2009), Capturing adenylyl cyclases as potential drug targets; Nat. Rev. Drug Discov., 8 321
3) Brand et al. (2013), Isoform selectivity of adenylyl cyclase inhibitor: characterization of known and novel compounds; J. Pharmacol. Exp. Therap., 347 265
4) Oritz-Capisano et al. (2007), Adenylyl cyclase isoform V mediates renin release from juxtaglomerular cells; Hypertension, 49 618
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
NKY-80 (299442-43-6) is a potent and selective adenylyl cyclase inhibitor. Selective for AC5 and over AC3 and AC2 (IC50 = 8.3 μM, 132 μM and 1.7 mM respectively).1,2 More recently shown to indiscriminately inhibit AC6.3 NKY-80 is an extremely useful tool for probing the involvement of adenylyl cyclases in cellular signaling.4
References/Citations:
1) Onda et al. (2001), Type-specific regulation of adenylyl cyclase. Selective pharmacological stimulation and inhibition of adenylyl cyclase isoforms; J. Biol. Chem., 276 47785
2) Pierre et al. (2009), Capturing adenylyl cyclases as potential drug targets; Nat. Rev. Drug Discov., 8 321
3) Brand et al. (2013), Isoform selectivity of adenylyl cyclase inhibitor: characterization of known and novel compounds; J. Pharmacol. Exp. Therap., 347 265
4) Oritz-Capisano et al. (2007), Adenylyl cyclase isoform V mediates renin release from juxtaglomerular cells; Hypertension, 49 618
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