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Product Details

NLG919 | IDO pathway inhibitor

NLG919 (1402836-58-1) is a potent IDO-pathway inhibitor (Ki = 7nM; EC50 = 75nM).1 It synergizes with chemo-radiation therapy to promote T cell dependent complement deposition in a murine model of glioblastoma.2 In combination with paclitaxel in a mouse B16-F10 melanoma model, NLG919 increased the percentage of CD3+, CD8+, and CD4+ T cells and secretion of IFN-γ and interleukin-2 while decreasing the percentage of CD4+CD25+ regulatory T cells.3

References/Citations

1) Mautino et al. (2013), NLG919, a novel indolamine-2,3-dioxygenase (IDO)-pathway inhibitor drug candidate for cancer therapy; Cancer Res. 73 issue 8 supplement 491
2) Li et al. (2014), The indolamine 2,3-dioxygenase pathway controls complement-dependent enhancement of chemo-radiation therapy against murine glioblastoma; J. Immunother. Cancer 21
3) Meng et al. (2017), Combinatorial antitumor effects of indoleamine 2,3-dioxygenase inhibitor NLG919 and paclitaxel in a murine B16-F10 melanoma model; Int. J. Immunopathol. Pharmacol. 30 215

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Catalog#  10-4564-0005

$60.00
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CAS:
1402836-58-1
Catalog Number:
10-4564
Activity:
IDO pathway inhibitor
Chemical Name:
1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol
Molecular Weight:
282.39
Molecular Formula:
C18H22N2O
Solubility:
Soluble in DMSO (up to 15 mg/ml)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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