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NLRP3i | NLRP3 inflammasome inhibitor

NLRP3i (16673-34-0) is an NLRP3 inflammasome inhibitor which likely acts via interfering with the formation of the NLRP3 inflammasome complex and which exhibits promising in vivo protective activities in mouse acute myocardial infarction models. It blocks ASC aggregation, blocks the release of IL-1β and the activation of caspase-1 in macrophages expressing constitutively active NLRP3 but does not directly inhibit caspase-1.1,2 Limits infarct size after myocardial ischemia-reperfusion as well as leukocyte infiltration in a peritonitis model in mice.2

References/Citations
1) Fulp et al. (2018), Structural Insights of Benzenesulfonamide Analogues as NLRP3 Inflammasome Inhibitors: Design, Synthesis, and Biological Characterization; J. Med. Chem., 61 5412
2) Marchetti et al. (2014), A novel pharmacologic inhibitor of the NLRP3 inflammasome limits myocardial injury after ischemia-reperfusion in the mouse; J. Cardiovas. Pharmacol., 63 316

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Catalog#  10-3672-0020

$50.00
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CAS:
16673-34-0
Catalog Number:
10-3672
Activity:
NLRP3 inflammasome inhibitor
Chemical Name:
4-[2-(5-Chloro-2-methoxybenzamido)ethyl]phenylsulfonamide
Alternate Name:
JC121
Molecular Weight:
368.84
Molecular Formula:
C16H17ClN2O4S
Solubility:
Soluble in DMSO (up to 45 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT (des.)
Stability:
Stable for 3 years as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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