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Product Details

NNGH | MMP inhibitor (pan specific)

NNGH (161314-17-6) is a potent pan-specific inhibitor of matrix metalloproteinases ( MMP3 Ki=0.013 μM). Inhibits MMP-1, -2, -7-10, -12-14 and MMP-20. Attenuates inflammation-induced thermal hyperalgesia. Cell Permeable.

References/Citations
1) MacPherson et al. (1997), Discovery of CGS 27023A, a non-peptidic, potent, and orally active stromelysin inhibitor that blocks cartilage degradation in rabbits; J. Med. Chem., 40 2525
2) Jeng et al. (1998), Sulfonamide-based hydroxamic acids as potent inhibitors of mouse macrophage metalloelastase; Bioorg. Med. Chem. Lett., 8 897
3) Christianson et al. (2012), Spinal matrix metalloproteinase 3 mediates inflammatory hyperalgesia via a tumor necrosis factor-dependent mechanism; J. Neuroscience, 200 199

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NNGH | 161314-17-6 | Structure | supplier

Catalog#  10-1045

$55.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
161314-17-6
Catalog Number:
10-1045
Activity:
MMP inhibitor (pan spec.)
Chemical Name:
N-Isobutyl-N-(4-methoxyphenylsulfonyl)glycyl hydroxamic acid
Molecular Weight:
316.38
Molecular Formula:
C13H20N2O5S
Solubility:
Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 8 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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