NNGH (161314-17-6) is a potent pan-specific inhibitor of matrix metalloproteinases ( MMP3 Ki=0.013 μM). Inhibits MMP-1, -2, -7-10, -12-14 and MMP-20. Attenuates inflammation-induced thermal hyperalgesia. Cell Permeable.
1) MacPherson et al. (1997), Discovery of CGS 27023A, a non-peptidic, potent, and orally active stromelysin inhibitor that blocks cartilage degradation in rabbits; J. Med. Chem., 40 2525
2) Jeng et al. (1998), Sulfonamide-based hydroxamic acids as potent inhibitors of mouse macrophage metalloelastase; Bioorg. Med. Chem. Lett., 8 897
3) Christianson et al. (2012), Spinal matrix metalloproteinase 3 mediates inflammatory hyperalgesia via a tumor necrosis factor-dependent mechanism; J. Neuroscience, 200 199