Nonactin (6833-84-7) is a monovalent cation ionophore with high selectivity for NH4+ and K+ 1. Upregulates levels of mitochondrial stress proteins HSP58 and GRP752. Nonactin abolishes mitochondrial membrane potential3.
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2) Mizzen et al. (1989), Identification, characterization and purification of two mammalian stress proteins present in mitochondria, grp 75, a member of the hsp 70 family and hsp 58, a homolog of the bacterial groEL protein; J. Biol. Chem., 264 20664
3) Dudani et al. (1990), Effects of antimitotic and antimitochondrial agents on the cellular distribution of microtubules and mitochondria; Cytobios, 63 95