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Nonactin | Monovalent cation ionophore K+ and NH4+

Nonactin (6833-84-7) is a monovalent cation ionophore with high selectivity for NH4+ and K+ 1. Upregulates levels of mitochondrial stress proteins HSP58 and GRP752. Nonactin abolishes mitochondrial membrane potential3.

1) Garcia et al. (2003), Determination of potassium ions in pharmaceutical samples by FIA using a potentiometric electrode based on ionophore nonactin occulded in EVA membrane; J. Pham. Biomed. Anal., 31 11
2) Mizzen et al. (1989), Identification, characterization and purification of two mammalian stress proteins present in mitochondria, grp 75, a member of the hsp 70 family and hsp 58, a homolog of the bacterial groEL protein; J. Biol. Chem., 264 20664
3) Dudani et al. (1990), Effects of antimitotic and antimitochondrial agents on the cellular distribution of microtubules and mitochondria; Cytobios, 63 95

Focus Biomolecules supplier, chemical structure of Nonactin | Monovalent cation ionophore K+ and NH4+ | CAS 6833-84-7

Catalog#  10-2090

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Catalog Number:
Monovalent cation ionophore (K+ and NH4+)
Alternate Names:
Polynactin; Werramycin A
Chemical Name:
Isolated from Streptomyces griseus
Molecular Weight:
Molecular Formula:
Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to 10 mg/ml).
Physical Properties:
White solid
99% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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