Nonylbenzeneboronic acid (CAS 256383-45-6) is a potent and selective inhibitor of fatty acid amide hydrolase (FAAH, the enzyme which hydrolyzes and deactivates anandamide), IC50=9.1 nM1. Also inhibits monoacylglycerol lipase (MAGL, the enzyme which hydrolyzes 2-arachidonoyl-glycerol), IC50=7.9 μM.1
References/Citations
1) Minkkila et al. (2008), Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase; J. Med. Chem., 51 7057
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