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Noopept | Nootropic and neuroprotective agent

Noopept (157115-85-0) is a novel proline-containing dipeptide with nootropic and cognition-enhancing activity.1 Rescues α-synuclein amyloid toxicity in cellular models.2 Stimulates the expression of NGF and BDNF in rat hippocampus.3 Improves viability of hippocampal HT-22 neurons in a glutamate toxicity model.4 Normalizes blood glucose level and tolerance to glucose load in a streptozotocin diabetic rat model of developing diabetes.5

References/Citations

1) Ostrovskaya et al. (2007), The nootropic and neuroprotective proline-containing dipeptide noopept restores spatial memory and increases immunoreactivity to amyloid in an Alzheimer’s disease model; J. Psychopharmacol., 21 611
2) Jia et al. (2011), Neuroprotective and nootropic drug noopept rescues α-synuclein amyloid cytotoxicity; J. Mol. Biol., 414 699
3) Ostrovskaya et al. (2008), Noopept stimulates the expression of NGF and BDNF in rat hippocampus; Bull. Exp. Biol. Med., 146 334
4) Antipova et al. (2016), Dipeptide Piracetam Analogue Noopept Improves Viability of Hippocampal HT-22 Neurons in the Glutamate Toxicity Model; Bull. Exp. Biol. Med., 161 58
5) Ostrovskaya et al. (2014), Comparative activity of proline-containing dipeptide noopept and inhibitor of dipeptidyl peptidase-4 sitagliptin in a rat model of developing diabetes; Bull. Exp. Biol. Med., 156 342

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Focus Biomolecules reagent supplier, chemical structure of Noopept | Nootropic & neuroprotective agent | CAS 157115-85-0

Catalog#  10-2682-0010

$50.00
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CAS:
157115-85-0
Catalog Number:
10-2682
Short Description:
Nootropic and neuroprotective agent
Chemical Name:
1-(2-Phenylacetyl)-L-prolyl-glycine ethyl ester
Alternate Names:
SGS-111; GVS 111
Molecular Weight:
318.37
Molecular Formula:
C17H22N2O4
Solubility:
Soluble in DMSO (up to 25 mg/ml)
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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