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Norquetiapine 2HCl | Quetiapine metabolite

Norquetiapine 2HCl (111974-74-4) is a pharmacologically active metabolite of quetiapine (Seroquel).1  Exhibits distinct pharmacological activity from quetiapine and plays an important role in its antidepressant activity.2  Activates ERK1/2 and induces release of BDNF in C6 glioma cells which may contribute to the antidepressant properties of quetiapine.3 Inhibits the norepinephrine transporter which may contribute to the antipsychotic activity of quetiapine.4


1) Altamura et al. (2012), Effect of quetiapine and norquetiapine on anxiety and depression in major psychoses using a pharmacokinetic approach: a prospective observational study; Clin. Drug Investig., 32 213
2) Lopez Munoz and Alamo (2013), Active metabolites as antidepressant drugs: the role of norquetiapine in the mechanism of action of quetiapine in the treatment of mood disorders; Front. Psychiatry, 4 102
3) Di. Benedetto et al. (2012), N-desalkylquetiapine activates ERK1/2 to induce GDNF release in C6 glioma cells: a putative cellular mechanism for quetiapine as antidepressant; Neuropharmacology, 62 209
4) Bjorkholm et al. (2013), Role of concomitant inhibition of the norepinephrine transporter for the antipsychotic effect of quetiapine; Eur. Neuropsychopharmacol., 23 709

Focus Biomolecules cell signaling supplier, chemical structure Norquetiapine 2HCl | Quetiapine metabolite | CAS 111974-74-4

Catalog#  10-2588-0050

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Catalog Number:
Quetiapine metabolite
Chemical Name:
11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride
Molecular Weight:
Molecular Formula:
C17H17N3S • 2HCl
Soluble in DMSO, Methanol, Distilled Water
Physical Properties:
Off-white solid
98% by TLC
NMR (Conforms)
Storage Temperature:
RT (des.)
Stable for 1 year as supplied. Solutions in DMSO, methanol, or distilled water may be stored at -20°C for up to 3 months.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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