NPC-15437 | PKC inhibitor

Potent and selective inhibitor of protein kinase C which binds to the regulatory domain (IC₅₀=19 mM).^1,2 It specifically interacts with the C1 domain of PKC.³ Important tool for assessing the role of PKC in various signaling pathways.⁴  Cell permeable. Active in vivo.⁴

References/Citations
1) Sullivan et al. (1992), 2,6-Diamino-N-([1-(1-oxotridecyl)-2-piperidinyl]methyl)hexanamide (NPC 15437): a novel inhibitor of protein kinase C interacting at the regulatory domain; Mol. Pharmacol., 41 38
2) Sullivan et al. (1991), 2,6-Diamino-N-([1-oxotridecyl)-2-piperidinyl]methyl)hexanamide (NPC 15437): a selective inhibitor of protein kinase C; Agents Actions 34 142
3) Sullivan et al. (1991), NPC 15437 interacts with the C1 domain of protein kinase C. An analysis using mutant PKC constructs; FEBS Lett., 285 120
4) Miyoshi et al. (2007), mGlu5 receptor and protein kinase C implicated in the development and induction of neuropathic pain nnfollowing chronic ethanol consumption; Eur. J. Pharmacol., 562 208