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Product Details

NPC-15437 | PKC inhibitor

Potent and selective inhibitor of protein kinase C which binds to the regulatory domain (IC50=19 mM).1,2 It specifically interacts with the C1 domain of PKC.3 Important tool for assessing the role of PKC in various signaling pathways.4  Cell permeable. Active in vivo.4

References/Citations
1) Sullivan et al. (1992), 2,6-Diamino-N-([1-(1-oxotridecyl)-2-piperidinyl]methyl)hexanamide (NPC 15437): a novel inhibitor of protein kinase C interacting at the regulatory domain; Mol. Pharmacol., 41 38
2) Sullivan et al. (1991), 2,6-Diamino-N-([1-oxotridecyl)-2-piperidinyl]methyl)hexanamide (NPC 15437): a selective inhibitor of protein kinase C; Agents Actions 34 142
3) Sullivan et al. (1991), NPC 15437 interacts with the C1 domain of protein kinase C. An analysis using mutant PKC constructs; FEBS Lett., 285 120
4) Miyoshi et al. (2007), mGlu5 receptor and protein kinase C implicated in the development and induction of neuropathic pain nnfollowing chronic ethanol consumption; Eur. J. Pharmacol., 562 208

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Focus Biomolecules cell signaling reagent supplier, chemical structure of NPC-15437 | PKC inhibitor | CAS 141774-20-1

Catalog#  10-1387

$52.00
Quantity
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CAS:
141774-20-1
Catalog Number:
10-1387
Activity:
PKC inhibitor
Chemical Name:
(S)-2,6-Diamino-N-[(1-(1-oxotridecyl)-2-piperidinyl)methyl]hexanamide dihydrochloride hydrate
Molecular Weight:
511.61
Molecular Formula:
C25H50N4O2 2HCl
Solubility:
Soluble in Water (up to 10 mg/ml).
Physical Properties:
White or pale yellow solid / or lyophilized solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years as supplied. Solutions in distilled water may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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