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NSC-33994 | JAK2 inhibitor

NSC-33994 (82058-16-0) is a remarkably potent and selective JAK2 inhibitor (IC50 = 60 nM). Displays no effect on Src and TYK2 tyrosine kinase activity at a concentration of 25 μM1. Suppresses JAK2-V617F-mediated human pathological cell growth in vitro and in vivo2 and is concomitant with the disruption of intracellular vimentin filaments3. NSC-33994 reduces the tumorigenic potential of T98G glioblastoma cells in vitro and in vivo4.

References/Citations
1) Kiss et al. (2009), Identification of a novel inhibitor of JAK2 tyrosine kinase by structure-based virtual screening; Bioorg. Med. Chem. Lett., 19 3598
2) Kirabo et al. (2011),
The stilbenoid tyrosine kinase inhibitor, G6, suppresses Jak2-V617F-mediated human pathological cell growth in vitro and in vivo; J. Biol. Chem., 286 4280
3) Majumder et al. (2011), Cell death induced by the Jak2 inhibitor, G6, correlates with cleavage of vimentin filaments; Biochemistry, 50 7774
4) Baskin et al. (2014), The Jak2 small molecule inhibitor, G6, reduces the tumorigenic potential of T98G glipblastoma cells in vitro and in vivo; PLoS One, 9(8) e105568

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NSC-33994 | 82058-16-0 | Structure | Supplier

Catalog#  10-1530

$85.00
Quantity
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CAS:
82058-16-0
Catalog Number:
10-1530
Activity:
JAK2 inhibitor
Alternate Names:
G6
Chemical Name:
E-4,4'-(1,2-Diethyl-1,2-ethenediyl)bis[2-[(diethylamino)methyl]phenol
Molecular Weight:
436.65
Molecular Formula:
C28H42N2O2
Solubility:
Soluble in DMSO (up to 2 mg/ml with warming) or in Ethanol (up to 4 mg/ml with warming).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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