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Product Details

NSC-405020 | MT-MMP inhibitor

NSC-405020 (7497-07-6) is a membrane type-1 matrix metalloproteinase (MMP14 or MT1-MMP) inhibitor that prevents homodimerization and inhibits MMP14’s protumorigenic activity in vivo. (IC50 > 100 μM). Inhibition is via interaction with the hemopexin domain (PEX) of MMP14. NSC-405020 does not interfere with the catalytic activity of MT1-MMP or MMP-2.  Suppresses bone erosion in a c-Fos-deficient mouse model.2 Decreases arsenic-mediated invasion of human squamous cell carcinoma HSC5 cells.3


1) Remacle et al. (2012), Novel MT1-MMP small-molecule inhibitors based on insights into hemopexin domain function in tumor growth;  Cancer Res., 72 2339
2) Kittaka et al. (2018) Cherubism Mice Also Deficient in c-Fos Exhibit Inflammatory Bone Destruction Executed by Macrophages That Express MMP14 Despite the Absence of TRAP+ Osteoclasts ; J. Bone Miner. Res., 33 167
3) Thang et al. (2014) Bidirectional functions of arsenic as a carcinogen and an anti-cancer agent in human squamous cell carcinoma; PLoS One, 9(5) e96945

Focus Biomolecules cell signaling reagent supplier, chemical structure of NSC-405020 | MT-MMP inhibitor | CAS 7497-07-6

Catalog#  10-1462

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Catalog Number:
MT-MMP inhibitor
Chemical Name:
Molecular Weight:
Molecular Formula:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
Physical Properties:
White solid
98% by TLC
NMR (Conforms)
Storage Temperature:
Room temperature (des.)
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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