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Product Details

NSC-47924 | PHLP phosphatase inhibitor / Laminin inhibitor

A potent inhibitor of the Leucine-rich repeat protein phosphatase (PHLPP) an enzyme which is a negative regulator of Akt and PKC (IC50=4 μM).1 Increases AKT signaling in cells and prevents apoptosis. Also inhibits the 67 kDa laminin receptor (LR) interaction with laminin (LM) and selectively blocks LR-293 cell adhesion to LM IC50=19.35 μM) impairing cell migration and invasion.2 Affects 37/67 kDa LR cell surface localization and interaction with cellular prion protein.3

References/Citations

1) Sierecki et al. (2010), Discovery of small molecule inhibitors of the PH domain leucine-rich repeat protein phosphatase PHLPP by chemical and virtual screening; J. Med. Chem., 53 6899
2) Pesapane et al. (2015), Discovery of new small molecules inhibiting 67 kDa laminin receptor interaction with laminin and cancer cell invasion; Oncotarget, 6 18116
3) Samataro et al. (2016), The 37/67 kDa laminin receptor (LR) inhibitor, NSC47924, affects 37/67 kDa LA cell surface localization and interaction with the cellular prion protein; Sci. Rep., 6 24457

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Catalog#  10-1562-0005

$60.00
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Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
6638-24-0
Catalog Number:
10-1562
Activity:
PHLP phosphatase inhibitor / Laminin inhibitor
Chemical Name:
1-((4-Methoxyanilino)methyl)-2-naphthol
Molecular Weight:
279.33
Molecular Formula:
C18H17NO2
Solubility:
Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 10 mg/ml with warming)
Physical Properties:
Yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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