my account
Login
  Loading... Please wait...

Product Details

NSC-632839 | DUB inhibitor

NSC-632839 (157654-67-6) is a pan-specific ubiquitin isopeptidase inhibitor. (IC50= 45, 37 and 9.8 μM for USP2, USP7 and SENP2 respectively) Does not effect proteasome proteolytic activity. NSC-632839 induces apoptosis via a Bcl-2-dependent but apoptosome-independent mitochondrial pathway.1,2 Cell permeable.

References/Citations
1) Aleo et al. (2006), Identification of new compounds that trigger apoptosome-independent caspase activation and apoptosis; Cancer Res., 66 9235
2) Nicholson et al. (2008), Characterization of ubiquitin and ubiquitin-like-protein isopeptidase activities; Protein Sci. 17 1035

swipe
NSC-632839 | 157654-67-6 | Structure | Supplier

Catalog#  10-1385

$65.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
Request Bulk Quote
CAS:
157654-67-6
Catalog Number:
10-1385
Activity:
DUB inhibitor
Alternate Names:
F6
Chemical Name:
3,5-Bis[(4-methylphenyl)methylene]-4-piperidone hydrochloride
Molecular Weight:
339.86
Molecular Formula:
C21H21NO HCl
Solubility:
Soluble in DMSO (up to 8 mg/ml).
Physical Properties:
Yellow solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

Connect with Focus

Click the button below to add the NSC-632839 | DUB inhibitor to your wish list.