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Product Details

NSC-66811 | p53/mdm2 inhibitor

NSC-66811 (6964-62-1) is a novel inhibitor of the MDM2-p53 interaction. Mimics three p53 residues involved in binding to MDM2. NSC-66811 binds to MDM2 with a Ki of 120 nM. Activates p53 in cancer cells. Cell permeable.

References/Citations
1) Lu et al. (2006), Discovery of a nanomolar inhibitor of the human murine double minute 2 (MDM2)-p53 interaction through an integrated, virtual database screening strategy; J. Med. Chem., 49 3759

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NSC-66811 | 6964-62-1 | Structure | Supplier

Catalog#  10-1334

$100.00
Quantity
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CAS:
6964-62-1
Catalog Number:
10-1334
Activity:
p53/mdm2 inhibitor
Chemical Name:
2-Methyl-7-[Phenyl(phenylamino)methyl]-8-quinolinol
Molecular Weight:
340.43
Molecular Formula:
C23H20N2O
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
White solid
Purity:
97% by TLC/HPLC
NMR (Conforms)
Storage Temperature:
RT (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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