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Product Details

NSC-697923 | Ubiquitin E2 Conjugating enzyme inhibitor

NSC-69723 (343351-67-7) is a selective inhibitor of E2 ubiquitin-conjugating enzyme, Ubc13-Uev1A. Does not inhibit UbcH5c activity. Impedes the formation of the Ubc13 and inhibits NF-κB activation in activated B cell-like diffuse large B-cell lymphoma (ABC-DLBCL) cells.1 Blocks proliferation and survival of both ABC-DLBCL and germinal center B cell-like (GCB)-DLBCL cell lines, and survival of primary DLBCL cells. NSC-69723 acts via covalent bonding to E2 active site thiol.2,3 Induces neuroblastoma cell death via activation of p53 and JNK.4

References/Citations

1) Pulvino et al. (2012), Inhibition of proliferation and survival of diffuse large B-cell lymphoma cells by a small-molecule inhibitor of the ubiquitin-conjugating enzyme Ubc13-Uev1A; Blood, 120 1668
2) Strickson et al. (2013), The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system; Biochem. J., 451 427
3) Hodge et al. (2015), Covalent Inhibition of Ubc13 Affects Ubiquitin Signaling and Reveals Active Site Elements Important for Targeting; ACS Chem. Biol., 10 1718
4) Cheng et al. (2014), A small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways; Cell Death Dis., 5 e1079

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NSC-697923 | 343351-67-7 | Structure | Supplier

Catalog#  10-1418-0005

$50.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
343351-67-7
Catalog Number:
10-1418
Activity:
Ubiquitin E2 conjugating enzyme inhibitor
Chemical Name:
2-[(Methylphenyl)sulfonyl]-5-nitrofuran
Molecular Weight:
267.26
Molecular Formula:
C11H9NO5S
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 5 mg/ml with warming)
Physical Properties:
Pink solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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