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Product Details

NSC-697923 | Ubiquitin E2 Conjugating enzyme inhibitor

NSC-69723 (343351-67-7) is a selective inhibitor of E2 ubiquitin-conjugating enzyme, Ubc13-Uev1A. Does not inhibit UbcH5c activity. Impedes the formation of the Ubc13 and inhibits NF-κB activation in activated B cell-like diffuse large B-cell lymphoma (ABC-DLBCL) cells.1 Blocks proliferation and survival of both ABC-DLBCL and germinal center B cell-like (GCB)-DLBCL cell lines, and survival of primary DLBCL cells. NSC-69723 acts via covalent bonding to E2 active site thiol.2,3 Induces neuroblastoma cell death via activation of p53 and JNK.4


1) Pulvino et al. (2012), Inhibition of proliferation and survival of diffuse large B-cell lymphoma cells by a small-molecule inhibitor of the ubiquitin-conjugating enzyme Ubc13-Uev1A; Blood, 120 1668
2) Strickson et al. (2013), The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system; Biochem. J., 451 427
3) Hodge et al. (2015), Covalent Inhibition of Ubc13 Affects Ubiquitin Signaling and Reveals Active Site Elements Important for Targeting; ACS Chem. Biol., 10 1718
4) Cheng et al. (2014), A small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways; Cell Death Dis., 5 e1079

Focus Biomolecules supplier, chemical structure of NSC-697923 | Ubiquitin E2 Conjugating enzyme inhibitor | CAS 343351-67-7

Catalog#  10-1418-0005

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Catalog Number:
Ubiquitin E2 conjugating enzyme inhibitor
Chemical Name:
Molecular Weight:
Molecular Formula:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 5 mg/ml with warming)
Physical Properties:
Pink solid
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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