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NSC 95397 | CtBP inhibitor; Cdc25 phosphatase inhibitor

NSC 95397 (93718-83-3) is a potent and selective inhibitor of Cdc25 phosphatase (Ki  = 32, 96 and 40 nM for Cdc25A, B and C respectively). NSC-95397 inhibits the growth of several human tumor cell lines and blocks G2/M cell cycle transition.1 Induces cell cycle arrest, phosphorylation of EGFR and activation of ERK-1 and -2.2 Inhibits carboxyl-terminal binding protein a transcriptional corepressor that suppresses multiple pro-apoptotic and epithelial genes.3 Induces eryptosis in human erythrocytes.4

References/Citations

1) Lazo et al. (2002), Identification of a potent and selective pharmacophore for Cdc25 dual specificity phosphatase inhibitors; Mol. Pharmacol., 61 720
2) Melchheier et al. (2005), Quinone-induced Cdc25A inhibition causes ERK-dependent connexin phosphorylation; Biochem. Biophys. Res. Commun., 327 1016
3) Blevins et al. (2015), Small Molecule, NSC95397, inhibits the CtBP1-Protein Partner Interaction and CtBP1-Mediated Transcriptional Repression; J. Biomol. Screen., 20 663
4) Jemaa et al. (2016), Stimulation of Suicidal Erythrocyte Death by the CDC25 Inhibitor NSC-95397; Cell. Physiol. Biochem., 40 597

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NSC 95397 | 93718-83-3 | Structure | Supplier

Catalog#  10-1565-0005

$80.00
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CAS:
93718-83-3
Catalog Number:
10-1565
Activity:
CtBP inhibitor; Cdc25 phosphatase inhibitor
Chemical Name:
2,3-bis[(2-Hydroxyethyl)thiol]-1,4-naphthoquinone
Molecular Weight:
310.39
Molecular Formula:
C14H14O4S2
Solubility:
Soluble in DMSO (up to 15 mg/ml) or in Ethanol (up to 1 mg/ml)
Physical Properties:
Orange solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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