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Product Details

NU7441 | DNA-PK inhibitor

NU7441 (503468-95-9) is a potent (IC50 = 13 nM) and selective ATP-competitive inhibitor of DNA-dependent protein kinase (DNA-PK).1,2 It increased the toxicity of ionizing radiation and etoposide on SW620 human colon cancer lines via impeding DNA double-strand break repair.3 NU7441 also increased the radio/chemosensitivity of various other cancer cell lines.3-6

References/Citations
1) Leahy et al. (2004), Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries; Bioorg. Med. Chem. Lett., 14 6083
2) Hardcastle et al. (2005), Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach: J. Med. Chem., 48 7829
3) Zhao et al. (2006), Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441: Cancer Res. 66 5354
4) Ciszewski et al. (2014), DNA-PK inhibition by NU7441 sensitizes breast cancer cells to ionizing radiation and doxorubicin: Breast Cancer Res. Treat., 143 83
5) Yang et al. (2016), NU7441 Enhances the Radiosensitivity of Liver Cancer Cells: Cell Physiol. Biochem., 38 1897
6) Geng et al. (2019), DNA-PKcs inhibitor increases the sensitivity of gastric cancer cells to radiotherapy: Oncol. Rep., epub. ahead of print

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Catalog#  10-4810-0005

$50.00
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Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
503468-95-9
Catalog Number:
10-4810
Activity:
DNA-PK inhibitor
Chemical Name:
8-Dibenzothiophen-4-yl-2-morpholin-4-ylchromen-4-one
Alternate Name:
Ku-57788
Molecular Weight:
413.49
Molecular Formula:
C25H19NO3S
Solubility:
Soluble in DMSO (up to 10 mg/ml with warming).
Physical Properties:
Off-white to beige solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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