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Product Details

NVP-BGJ398 | Pan-specific FGFR inhibitor

NVP-BGJ398 (872511-34-1) is a potent and selective pan-FGFR inhibitor (IC50 = 0.9nM, 1.4 nM, 1.0 nM, and 60 nM for FGFR1,2,3,4 respectively).1  It has also been used in a mouse model of Achondroplasia (most common form of dwarfism) to correct pathological hallmarks of this condition.

References/Citations

1) Guagnano et al. (2011), Discovery of 3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-(6-{[4-(4-ethyl-1-piperazinyl)phenyl]amino}-4-pyrimidinyl)-1-methylurea (NVP-BGJ398), a Potent and Selective Inhibitor of the Fibroblast Growth Factor Receptor Family of Receptor Tyrosine Kinase ; J. Med. Chem. 54 7066
2) Komla-Ebri et al. (2016), Tyrosine kinase inhibitor NVP-BGJ398 functionally improves FGFR3-related dwarfism in mouse model; J. Clin. Invest. 126 1871

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Focus Biomolecules cell signaling supplier, chemical structure of NVP-BGJ398 | Pan-specific FGFR inhibitor | CAS 87251-34-1

Catalog#  10-4817-0010

$65.00
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CAS:
87251-34-1
Catalog Number:
10-4817
Activity:
Pan-specific FGFR inhibitor
Chemical Name:
3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-(6-{[4-(4-ethyl-1-piperazinyl)phenyl]amino}-4-pyrimidinyl)-1-methylurea
Alternate Names:
Infigratinib
Molecular Weight:
560.48
Molecular Formula:
C26H31Cl2N7O3
Solubility:
Soluble in DMSO (up to 5 mg/ml)
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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