NVP-DK709 | IKZF2 degrader

CAS:
 2291360-73-9
Catalog Number:
 10-3468

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25 mg$280.00
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NVP-DKY709 (2291360-73-9) is a selective molecular glue degrader of IKZF2, selective over IKZF1/31. IKZF2 is a transcription factor that plays a crucial role in maintaining function and stability of Treg cells. Down-regulation of IKZF2 reduces cancer cell growth2. Treatment with NVP-DKY709 reduced the suppressive activity of human Treg cells and rescued cytokine production in exhausted T-effector cells1. Caution: May be teratogenic. Pregnant women should avoid all contact with this substance.

References/Citations:

  1. Bonazzi et al. (2023) Discovery and characterization of a selective IKZF2 glue degrader for cancer immunotherapy; Cell Chem. Biol. 30 235
  2. Park et al. (2019) IKZF2 Drives Leukemia Stem Cell Self-Renewal and Inhibits Myeloid Differentiation; Cell Stem Cell 24 153
2291360-73-9, IKZF2 degrader, IKZF2 protac, NVP-DKY709, NVP-DKY709 supplier
CAS:
2291360-73-9
Catalog Number:
10-3468
Activity:
IKZF2 degrader
Chemical Names:
3-[1,3-Dihydro-1-oxo-5-[1-(phenylmethyl)-4-piperidinyl]-2H-isoindol-2-yl]-2,6-piperidinedione
Molecular Weight:
417.56
Molecular Formula:

C25H27N3O3

Solubility:
Soluble in DMSO (10 mg/ml)
Physical Properties:
White solid
Purity:

>98% HPLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for up to 1 year when stored as supplied @ -20°C. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

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Product Data Sheet:

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Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

NVP-DKY709 (2291360-73-9) is a selective molecular glue degrader of IKZF2, selective over IKZF1/31. IKZF2 is a transcription factor that plays a crucial role in maintaining function and stability of Treg cells. Down-regulation of IKZF2 reduces cancer cell growth2. Treatment with NVP-DKY709 reduced the suppressive activity of human Treg cells and rescued cytokine production in exhausted T-effector cells1. Caution: May be teratogenic. Pregnant women should avoid all contact with this substance.

References/Citations:

  1. Bonazzi et al. (2023) Discovery and characterization of a selective IKZF2 glue degrader for cancer immunotherapy; Cell Chem. Biol. 30 235
  2. Park et al. (2019) IKZF2 Drives Leukemia Stem Cell Self-Renewal and Inhibits Myeloid Differentiation; Cell Stem Cell 24 153

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