NVS-STG2 | Molecular glue STING agonist
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $75.00 | ||
| 25 mg | $265.00 |
NVS-STG2 (3030588-01-0) is a STING agonist that activates human STING by binding in a pocket between the transmembrane domains of neighboring STING dimers in a molecular glue-like manner (AC50 = 5.2 µM). Inactive with mouse STING. NVS-STG2 slowed tumor growth significantly in MC38 tumors inoculated into hSTING knock-in mice.
References/Citations:
- Li et al. (2024), Activation of human STING by a molecular glue-like compound; Nat.Chem. Biol. 20 365
Safety Data Sheet:
Product Data Sheet:
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NVS-STG2 (3030588-01-0) is a STING agonist that activates human STING by binding in a pocket between the transmembrane domains of neighboring STING dimers in a molecular glue-like manner (AC50 = 5.2 µM). Inactive with mouse STING. NVS-STG2 slowed tumor growth significantly in MC38 tumors inoculated into hSTING knock-in mice.
References/Citations:
- Li et al. (2024), Activation of human STING by a molecular glue-like compound; Nat.Chem. Biol. 20 365
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