OAC2 | Enhances stem cell reprogramming

CAS:
 6019-39-2
Catalog Number:
 10-3203

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OAC2 (Oct4 Activating Compound 2; 6019-39-2) is an activator of octamer-binding transcription factor 4 (Oct4) which plays a role in self-renewal of undifferentiated embryonic stem cells and regulates embryonic stem cell pluripotency. Thus, OAC2 enhances iPSC reprogramming efficiency.1  OAC2 is one component in the 9C cocktail used to convert human fibroblasts to functional cardiomyocytes.2 It has been employed in the generation of chicken induced pluripotent stem cells from somatic cells using multi-lentiviral transduction.3

References/Citations:

  1. Li et al. (2012), Identification of Oct4-activating compounds that enhance reprogramming efficiency; Proc. Natl. Acad. Sci. USA 109 20853
  2. Cao et al. (2016), Conversion of human fibroblasts into functional cardiomyocytes by small molecules; Science 352 1216
  3. Liu et al. (2025), Generation of chicken induced pluripotent stem cells (iPSCs) from somatic cells using multi-lentiviral transduction and OAC2; Theriogenology 247 117567
6019-39-2, OAC2, OAC2 supplier, Oct4 activator
CAS:
6019-39-2
Catalog Number:
10-3203
Activity:
Enhances stem cell reprogramming
Chemical Names:
N-(1H-Indol-5-yl)benzamide
Molecular Weight:
236.27
Molecular Formula:

C15H12N2O

Solubility:
Soluble in DMSO (20 mg/ml)
Physical Properties:
Light brown solid
Purity:

>98% TLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for up to 2 years when stored as supplied @ room temperature. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Download Product Data Sheet

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OAC2 (Oct4 Activating Compound 2; 6019-39-2) is an activator of octamer-binding transcription factor 4 (Oct4) which plays a role in self-renewal of undifferentiated embryonic stem cells and regulates embryonic stem cell pluripotency. Thus, OAC2 enhances iPSC reprogramming efficiency.1  OAC2 is one component in the 9C cocktail used to convert human fibroblasts to functional cardiomyocytes.2 It has been employed in the generation of chicken induced pluripotent stem cells from somatic cells using multi-lentiviral transduction.3

References/Citations:

  1. Li et al. (2012), Identification of Oct4-activating compounds that enhance reprogramming efficiency; Proc. Natl. Acad. Sci. USA 109 20853
  2. Cao et al. (2016), Conversion of human fibroblasts into functional cardiomyocytes by small molecules; Science 352 1216
  3. Liu et al. (2025), Generation of chicken induced pluripotent stem cells (iPSCs) from somatic cells using multi-lentiviral transduction and OAC2; Theriogenology 247 117567

STEM CELL

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