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Obatoclax | Bcl-2 antagonist - Induces apoptosis

Obatoclax (803712-79-0) is a novel Bcl-2 homology domain-3 (BH3) mimetic.1 Inhibits primary acute myeloid leukemia (AML) progenitor cell proliferation (IC50=0.18 μM) and induces apoptosis in primary AML cells (IC50= 3.6 μM).2 Obatoclax synergizes with other agents such as chloroquine3 and cytarabine4(cat.# 10-1268) in cytotoxicity against a variety of cancer cells.

References/Citations
1) Chonghaile and Letai (2008), Mimicking the BH3 domain to kill cancer cells; Oncogene, 27 S149
2) Konopleva et al. (2008), Mechanisms of antileukemic activity of the novel Bcl-2 homology domain-3 mimetic GX15-070 (obatoclax); Cancer Res., 68 3413
3) Wang et al. (2014), Combination of chloroquine and GX15-070 (obatoclax) results in synergistic cytotoxicity against pancreatic cancer cells; Oncol. Rep., 32 2789
4) Xie et al. (2015), Obatoclax potentiates the cytotoxic effect of cytarabine on acute myeloid leukemia cells by enhancing DNA damage; Mol. Oncol., 9 409

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Catalog#  10-2660

$70.00
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CAS:
803712-79-0
Catalog Number:
10-2660
Activity:
BCL-2 antagonist - Induces apoptosis
Alternate Names:
GX15-070
Chemical Name:
2-[2-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene]-3-methoxy-2H-pyrrol-5-yl]-1H-indole methanesulfonate
Molecular Weight:
413.5
Molecular Formula:
C20H19N3O CH3SO3H
Solubility:
Soluble in DMSO (up to 5 mg/ml).
Physical Properties:
Purple solid
Purity:
98% by TLC
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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