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ODQ | Soluble guanylyl cyclase inhibitor

ODQ (41443-28-1) is a potent and selective inhibitor of soluble guanylyl cyclase (sGC), IC50 = 20 nM).1 ODQ acts via competition     with NO for the heme site of sGC where it binds irreversibly.2 ODQ does not inhibit NO-mediated macrophage toxicity, an activity that is unrelated to cGMP nor does it inhibit particulate GC.1 ODQ is an extremely useful tool to explore the involvement of the NO-cGMP pathway in cellular signaling and physiologic processes.3-5

1) Garthwaite et al. (1995), Potent and Selective Inhibition of Nitric Oxide-sensitive Guanylyl Cyclase by 1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one; Mol. Pharmacol. 48 184
2) Schrammel et al. (1996), Characterization of 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one as a heme-site inhibitor of nitric oxide-sensitive guanylyl cyclase; Mol. Pharmacol. 50 1
3) Estevez et al. (1998), Nitric oxide-dependent production of cGMP supports the survival of rat embryonic motor neurons cultured with brain-derived neurotrophic factor; J. Neurosci. 18 3708
4) Vandecasteele et al. (1998), Role of the NO-cGMP in the muscarinic regulation of the L-type Ca2+ current in human atrial myocytes; J. Physiol. 506 653
5) Martins-Pinge et al. (1999), Nitric oxide-dependent guanylyl cyclase participates in the glutamatergic neurotransmission within the rostral ventrolateral medulla of awake rats; Hypertension 34 748

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Catalog#  10-1211-0005

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Catalog Number:
Soluble guanylyl cyclase inhibitor
Chemical Name:
Molecular Weight:
Molecular Formula:
Soluble in DMSO (up to 40 mg/ml).
Physical Properties:
Pale yellow solid
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20° (des.)
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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