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Okadaic acid | Protein phosphatase inhibitor

Okadaic acid (78111-17-8) is a naturally occurring polyether marine toxin. Potent and selective inhibitor of protein phosphatases inhibiting PP2A completely at 1 nM and PP1 at higher concentrations, while PP2C is not inhibited. It is an extremely useful tool for studying cellular protein phosphorylation.2 Induces apoptosis in a variety of cell types.3 Okadaic acid activates atypical protein kinase isotypes and induces insulin-like effects in adipocytes.4 

Caution: SKIN IRRITANT, TUMOR PROMOTOR. Avoid contact.


1) Cohen et al. (1990), Okadaic acid: a new probe for the study of cellular regulation;  Trends Biochem. Sci., 15 98
2) Hardie et al. (1991), Use of okadaic acid to inhibit protein phosphatases in intact cells;  Clin. Methods Enzymol., 201 469
3) Haneji et al. (2013), Okadaic acid activates the PKR pathway and induces apoptosis through PKR stimulation in MG63 osteoblast-like cells;  J. Oncol., 42 1904
4) Standaert et al. (1999), Okadaic acid activates atypical protein kinase C (zeta/lambda) In rats and 3T3/L1 adipocytes. An apparent requirement for activation of Glut4 translocation and glucose transport;  J. Biol. Chem, 274 14074

Focus Biomolecules cell signaling supplier, chemical structure Okadaic acid | Protein phosphatase inhibitor | CAS 78111-17-8

Catalog#  10-2091

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Catalog Number:
Protein phosphatase inhibitor
Isolated from marine dionflagellates
Molecular Weight:
Molecular Formula:
Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 5 mg/ml).
Physical Properties:
Off-white solid
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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