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Oleoylethanolamide | GPR119 agonist: stimulates lipolysis

Endogenous anandamide-like lipid acting as a PPARα agonist but does not bind to cannabinoid receptors.1 Biosynthesis via the action of NAPE-PLD on N-acylphosphatidylethanolamine.2 Agonist at GPR1193 and has been suggested to be its endogenous ligand4. Inhibits food intake in rodents.5 Extends the lifespan of C. elegans.6


1) Lo Verme et al. (2005), Regulation of food intake by oleoylethanolamide; Cell Mol. Life Sci. 62 708
2) Magotti et al. (2015), Structure of human N-acylphosphatidylethanolamine-hydrolyzing phospholipase D: regulation of fatty acid ethanolamide biosynthesis by bile acids; Structure 23 598
3) Overton et al. (2006), Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecules hypophagic agents; Cell Metab. 3 167
4) Brown (2007), Novel cannabinoid receptors; Br. J. Pharmacol. 152 567
5) Nielson et al. (2004), Food intake is inhibited by oral oleoylethanolamide; J. Lipid Res. 45 1027
6) Folick et al. (2015), Aging. Lysosomal signaling molecules regulate longevity in Caenorhabditis elegans; Science 347 83

Focus Biomolecules supplier, chemical structure of Oleoylethanolamide | GPR119 agonist: stimulates lipolysis | CAS 111-58-0

Catalog#  10-1475-0010

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Catalog Number:
GPR119 agonist: Stimulates lipolysis
Chemical Name:
Alternate Names:
Molecular Weight:
Molecular Formula:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 35 mg/ml)
Physical Properties:
White solid
98% by TLC
NMR (Conforms)
Storage Temperature:
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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