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Product Details

Oltipraz | Nrf2 activator

Oltipraz (64224-21-1) upregulates the transcription factor NRF2 and prevents insulin resistance and obesity induced by high fat diet in C57BL/6J mice1. Attenuates the progression of fibrosis in a rat model of nonalcoholic steatohepatitis2. Oltipaz attenuates chronic hypoxia-induced cardiopulmonary alterations in mice3. Promotes liver regeneration after partial hepatectomy4. Off target effects: Activates constitutive androstane receptor (CAR)5.

References/Citations
1) Yu et al. (2011), Olipraz upregulates the nuclear factor (erythroid-derived 2)-like 2 (NRF2) antioxidant system and prevents insulin resistance and obesity induced by a high-fat diet in C57BL/6J mice; Diabetologia, 54 922
2) Shimozono et al. (2013), Nrf2 activators attenuate the progression of nonalcoholic steatohepatitis-related fibrosis in a dietary rat model; Mol. Pharmacol, 84 62
3) Eba et al. (2013), The nuclear factor erythroid 2-related factor 2 activator oltipraz attenuates chronic hypoxia-induced cardiopulmonary alterations in mice; Am. J. Respir. Cell. Mol. Biol., 49 324
4) Cho et al. (2009), Oltipraz promotion of liver regeneration after partial hepatectomy: the role of PI3-kinase dependent C/EBPbeta and cyclin E regulation; Arch. Pharm. Res., 32 625
5) Merrell et al. (2008), The Nrf2 activator oltipraz also activates the constitutive androstane receptor; Drug Metab. Dispos., 36 1716

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Catalog#  10-2831

$39.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
64224-21-1
Catalog Number:
10-2831
Activity:
Nrf2 activator
Chemical Name:
4-Methyl-5-pyrazinyl-3H-1,2-dithiole-3-thione
Molecular Weight:
226.34
Molecular Formula:
C8H6N2S3
Solubility:
Soluble in DMSO (up to 50 mg/ml).
Physical Properties:
Red solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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