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Product Details

Omeprazole | Proton pump inhibitor / Antiviral

Omeprazole (73590-58-6) is a H+,K+-ATPase inhibitor (IC50 = 5.8 μM). Clinically useful antisecretory and antiulcer agent.1 Potent inhibitor of CYP2C19 (Ki=3.1 mM).2 Inhibits swelling-dependent chloride channels.3 Facilitates oral bioavailability of bioactive peptides such as oxytocin by raising stomach pH.4 Displays broad spectrum antiviral activity.5 Enhances efficacy of remdesivir (10-fold).6

References/Citations
1) Satoh et al. (1989), Antisecretory and antiulcer activities of a novel proton pump inhibitor AG-1749 in dogs and rats; J. Pharmacol. Exp. Ther., 248 806
2) Kuzin et al. (2018), Effects of the Proton Pump Inhibitors Omeprazole and Pantoprazole on the Cytochrome P450-Mediated Metabolism of Venlafaxine; Clin. Pharmacokinet, 57 729
3) Schmarda et al. (2000) The gastric H,K-ATPase blocker Iansoprazole is an inhibitor of chloride channels; Br. J. Pharmacol., 129 598
4) Maejima et al. (2020), Oral oxytocin delivery with proton pump inhibitor pretreatment decreases food intake; Peptides, 128 170312
5) Wantanabe et al. (2020), Selective Targeting of Virus Replication by Proton Pump Inhibitors; Sci. Rep., 10 4003
6) Bojkova et al. (2020), SARS-CoV2 and SARS-CoV differ in their cell tropism and drug sensitivity profiles; bioRxiv, epub ahead of print DOI: 10.1101/2020.04.03.024257

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Catalog#  10-2822-0050

$38.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
73590-58-6
Catalog Number:
10-2822
Activity:
Proton pump inhibitor / Antiviral
Chemical Name:
5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole
Molecular Weight:
345.42
Molecular Formula:
C17H19N3O3S
Solubility:
Soluble in DMSO (up to 35 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 1 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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