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Product Details

Oridonin | Inflammasome inhibitor

Oridonin (28957-04-2) is a potent, covalent inhibitor of the NLRP3 inflammasome with anti-inflammatory activity in various mouse models.1 Inhibits vascular inflammation in vivo.2 Inhibits aberrant AKT activation in human breast cancer cells with hyperactivated PI3K/AKT signaling.3 Inhibits migration, invasion and adhesion of melanoma cells.4 Induces apoptosis in osteosarcoma cells by multiple pathways.5

References/Citations
1) He et al. (2018), Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity; Nat. Commun., 9 2550
2) Huang et al. (2018), Oridonin inhibits vascular inflammation by blocking NF-kB and MAPK activation; Eur. J. Pharmacol., 826 133
3) Sun et al. (2018), Oridonin inhibits aberrant AKT activation in breast cancer; Oncotarget, 9 23878
4) Li et al. (2018), Oridonin inhibits migration, invasion, adhesion and TGF-ß1-induced epithelial-mesenchymal transition of melanoma cells by inhibiting the activity of PI3K/Akt/GSK-3ß signaling pathway; Oncol. Lett., 15 1362
5) Lu et al. (2018), Oridonin exerts anticancer effect on osteosarcoma by activating PPARγ and inhibiting Nrf2 pathway; Cell Death Dis., 9 15

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Catalog#  10-2616-0010

$40.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
28957-04-2
Catalog Number:
10-2616
Activity:
HSP70 inhibitor
Chemical Name:
7a,20-Epoxy-1a,6b,7,14-tetrahydroxykaur-16-en-15-one
Alternate Name:
Isodonol
Molecular Weight:
364.43
Molecular Formula:
C20H28O6
Solubility:
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 10 mg/ml with warming).
Physical Properties:
White or off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20° (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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