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Oseltamivir Phosphate | Neuraminidase inhibitor / Antiviral

CAS:
204255-11-9
Catalog Number:
10-4483
Activity:
Neuraminidase inhibitor / Antiviral
Chemical Name:
Ethyl (3R,4R,5S)-4-acetamido-5-amino-3-pentan-3-yloxycyclohexene-1-carboxylate phosphoric acid salt
Alternate Name:
GS4104; Tamiflu
Molecular Weight:
410.40
Molecular Formula:
C16H28N2O4•H3PO4
Solubility:
Soluble in DMSO (up to 40 mg/ml) or in Water (up to at least 40 mg/ml).
Physical Properties:
White solid
Purity:
99% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
Shipping Code:
RT

Oseltamivir phosphate (204255-11-9) is a potent viral neuraminidase inhibitor and a clinically useful treatment for influenzas A and B.1,2 Oseltamivir is a prodrug that is converted to the active acid in vivo – IC50 for active acid in vitro = 2 nM.3

References/Citations:

1) Sidwell et al. (1998), Inhibition of influenza virus infections in mice by GS4104, an orally effective influenza virus neuraminidase inhibitor; Antiviral Res., 37 107
2) McClellan and Perry (2001), Oseltamivir: A Review of Its Use in Influenza; Drugs, 61 263
3) Li et al. (1998), Identification of GS4104 as an orally bioavailable prodrug of the influenza virus neuraminidase inhibitor GS4071; Antimicrob. Agents Chemother., 42 647

Oseltamivir Phosphate | Neuraminidase inhibitor / Antiviral is also available in the Cellular Metabolism Library.
CAS:
204255-11-9
Catalog Number:
10-4483
Activity:
Neuraminidase inhibitor / Antiviral
Chemical Name:
Ethyl (3R,4R,5S)-4-acetamido-5-amino-3-pentan-3-yloxycyclohexene-1-carboxylate phosphoric acid salt
Alternate Name:
GS4104; Tamiflu
Molecular Weight:
410.40
Molecular Formula:
C16H28N2O4•H3PO4
Solubility:
Soluble in DMSO (up to 40 mg/ml) or in Water (up to at least 40 mg/ml).
Physical Properties:
White solid
Purity:
99% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

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