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Oxaprozin | NFkB inhibitor

Oxaprozin (21256-18-8) is a clinically useful non-steroidal anti-inflammatory drug.1 In addition to typical NSAID COX inhibition, oxaprozin may also exert anti-inflammatory effects via inhibition of the Akt/IKK/NF-κB pathway.2 The compound is capable of inhibiting both anandamide hydrolase in neurons (IC50= 85 μmol/l), with consequent potent analgesic activity, and NF-κB activation in inflammatory cells (IC50 = 50 μmol/l).3

References/Citations
1) Merck 14:6924
2) Ottonello et al. (2009), Delayed apoptosis of human monocytes exposed to immune complexes is reversed by oxaprozin: role of the Akt/IkappaB kinase/nuclear factor kappaB pathway; Br. .J. Pharmacol., 157 294
3) Dallegri et al. (2005), A review of the emerging profile of the anti-inflammatory drug oxaprozin; Expert Opin .Pharmacother., 6 777

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Focus Biomolecules cell signaling reagent supplier, chemical structure of Oxaprozin | NFkB inhibitor | CAS 21256-18-8

Catalog#  10-1128

$40.00
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CAS:
21256-18-8
Catalog Number:
10-1128
Activity:
NFκB inhibitor
Chemical Name:
4,5-Diphenyl-2-oxazolepropanoic acid
Molecular Weight:
293.32
Molecular Formula:
C18H15NO3
Solubility:
Soluble in DMSO
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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