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Ozagrel HCl | Thromboxane synthase inhibitor

Ozagrel HCl (78712-43-3) is a potent and selective inhibitor of thromboxane (TXA2) synthetase (IC50 = 4 nM)1. Does not inhibit prostacyclin (PGI2) synthase, cyclooxygenase or PGE2 isomerase (IC50 > 1 mM)1. Inhibits platelet aggregation2 in vitro and arachidonate-induced arterial contraction in vivo. Oaagrel HCl protects against arachidonate-induced sudden death in the rabbit3, and alleviates liver injury induced by acetaminophen overdose in mice4.

1) Hiraku et al. (1986), Pharmacological studies on the TXA2 synthetase inhibitor (E)-3-[p-(1H-imidazol-1-ylmethyl)phenyl]-2-propenoic acid (OKY-046); Jpn. J. Pharmacol., 41 393
2) Naito et al. (1983), Effects of thromboxane synthetase inhibitors on aggregation of rabbit platelets; Eur. J. Pharmacol., 91 41
3) Edmonds and Leffer (1984), Protective actions of a new thromboxane synthetase inhibitor in arachidonate induced sudden death; Life Sci., 35 1763
4) Tomishima et al. (2013), Ozagrel hydrochloride, a selective thromboxane A2 synthase inhibitor, alleviates liver injury induced by acetaminophen overdose in mice; BMC Gastroenterol., 30 13

Focus Biomolecules reagent supplier, chemical structure of Ozagrel HCl | Thromboxane synthase inhibitor | CAS 78712-43-3

Catalog#  10-2767

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Catalog Number:
Thromboxane synthase inhibitor
Alternate Names:
Chemical Name:
(2E)-3-[4-(1H-Imidazol-1-ylmethyl)phenyl]-2-propenoic acid hydrochloride
Molecular Weight:
Molecular Formula:
C13H12N2O2 HCl
Soluble in Water (up to 25 mg/ml).
Physical Properties:
White solid
98% by HPLC
NMR (Conforms)
Storage Temperature:
RT (des.)
Stable for 2 years as supplied. Solutions in distilled water may be stored at -20° for up to 1 month.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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