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Product Details

Palbociclib | CDK4/CDK6 inhibitor

Palbociclib (571190-30-2) is a potent and selective inhibitor of Cdk4, IC50 = 11 nM and Cdk6, IC50 = 16 nM.1 Inhibits phosphorylation of Rb protein and cell cycle progression through G1 in primary 5T33MM cells and sensitized these cells to killing by a proteasome inhibitor (bortezomib) in mouse models.2 Induces autophagy and senescence in AGS gastric cancer cells. Clinically useful breast cancer agent.4 Cell cycle inhibitors boost tumor immunogenicity.5

References/Citations

1) El-Rayes et al. (2004), Cyclooxygenase-2-dependent and –independent effects of celecoxib in pancreatic cancer cell lines; Mol. Cancer Ther., 3 1427
2) Menu et al. (2008), A novel therapeutic combination using PD 0332991 and bortezomib: study in 5T33MM myeloma model; Cancer Res., 68 5519
3) Valenzuela et al. (2017), Palbociclib-induced autophagy and senescence in gastric cancer cells; Exp. Cell Res., 360 390
4) Palanisamy et al. (2016), Palbociclib: A new hope in the treatment of breast cancer; J. Cancer Res. Ther., 12 1220
5) Goel et al. (2017), CDK4/6 inhibition triggers anti-tumour immunity; Nature 548 471

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Focus Biomolecules cell signaling supplier, chemical structure of Palbociclib | CDK4/CDK6 inhibitor | CAS 571190-30-2

Catalog#  10-4760-0005

$50.00
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CAS:
571190-30-2
Catalog Number:
10-4760
Activity:
CDK4/CDK6 inhibitor
Chemical Name:
6-Acetyl-8-cyclopentyl-5-methyl-2-[[5-piperazin-1-yl)pyridine-2-yl]amino]-8H-pyrido[2,3-d]pyrimidin-7-one
Alternate Names:
PD-332991
Molecular Weight:
447.53
Molecular Formula:
C24H29N7O2
Solubility:
Soluble in DMSO (up to 2 mg/ml with warming)
Physical Properties:
Yellow solid
Purity:
99% by HPLC/TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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