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Product Details

Panobinostat | HDAC inhibitor

Panobinostat (404950-80-7) is a potent inhibitor of class I and II HDACs.1 Cotreatment with panobinostat and an HSP90 inhibitor caused synergistic apoptosis in human CML-BC and AML cells.2 A potent antimyeloma agent that overcomes drug resistance.3

References/Citations
1) Geng et al. (2006), Histone deacetylase (HDAC) inhibitor LBH589 increases duration of gamma H2AX foci and confines HDAC4 to the cytoplasm in irradiated non-small cell lung cancer; Cancer Res., 66 11298
2) George et al. (2005), Combination of the histone deacetylase inhibitor LBH589 and the hsp90 inhibitor 17-AAG is highly active against human CML-BC cells and AML cells with activating mutation of FLT-3; Blood, 105 1768
3) Maiso et al. (2006), The histone deacetylase inhibitor LBH589 is a potent antimyeloma agent that overcomes drug resistance; Cancer Res., 66 5781

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Focus Biomolecules cell signaling reagent supplier, chemical structure of Panobinostat | HDAC inhibitor | CAS 404950-80-7

Catalog#  10-2157

$60.00
Quantity
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CAS:
404950-80-7
Catalog Number:
10-2157
Activity:
HDAC inhibitor
Alternate Names:
LBH-589
Chemical Name:
(E)-N-Hydroxy-3-(4-((2-(2-methyl-1H-indol-3-yl)ethylamino)methyl)phenyl)acrylamide
Molecular Weight:
349.44
Molecular Formula:
C21H23N3O2
Solubility:
Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 5 mg/ml with warming).
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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