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Product Details

Parthenolide | NFkB inhibitor

Parthenolide (20554-84-1) binds to, and directly inhibits IκB kinase, resulting in the inhibition of the release of various mediators and inhibition of MAP kinase activation. Parthenolide demonstrates anti-inflammatory, antisecretory, and spasmolytic activities in vivo.

References/Citations
1) Kwok et al. (2001), The anti-inflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IkappaB kinase; Chem. Biol., 8 759
2) Hwang et al. (1996), Inhibition of the expression of inducible cyclooxygenase and proinflammatory cytokines by sequiterpene lactones in macrophages correlates with the inhibition of MAP kinases; Biochem. Biophys. Res. Commun., 226 810
3) Barsby et al. (1992), Feverfew extractss and parthenolide irreversibly inhibit vascular responses of the rabbit aorta; J. Pharm. Pharmacol., 44 737
4) Sumner et al. (1992), Inhibition of 5-lipoxygenase and cyclo-oxygenase in leukocytes by feverfew. Involvement of sesquiterpene lactones and other components; Biochem. Pharmacol., 43 2313
5) Groenewegen et al. (1990), A comparison of the effects of an extract of feverfew and parthenolide, a component of feverfew, on human platelet activity in-vitro; J. Pharm. Pharmacol., 42 553

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Catalog#  10-2096

$60.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
20554-84-1
Catalog Number:
10-2096
Activity:
NFκB inhibitor
Molecular Weight:
248.32
Molecular Formula:
C15H20O3
Solubility:
Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 20 mg/ml)
Physical Properties:
White solid
Purity:
97% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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