PAT-1251 | LOXL2 inhibitor

CAS:
 2098884-53-6
Catalog Number:
 10-4976
PAT-1251 chemical structure

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PAT-1251 (2098884-53-6) is a potent (IC50 = 710 nM) inhibitor of LOXL2, a copper-dependent amine oxidase that deaminates lysine and hydroxylysine residues in collagen and elastin. It displayed >400-fold selectivity over LOX as well as high selectivity against the related amine oxidases SSAO, DAO, and MAO-A/B.  A potential new therapeutic for the treatment of fibrotic diseases.

References/Citations:

  1. Rowbottom et al. (2017), Identification of 4-(Aminomethyl)-6-(trifluoromethyl)-2-(phenoxy)pyridine Derivatives as Potent, Selective, and Orally Efficacious Inhibitors of the Copper-Dependent Amine Oxidase, Lysyl Oxidase-Like 2 (LOXL2); J. Med. Chem. 60 4403
2007885-39-2, 2098884-53-6, Lenumlostat, Lenumlostat hydrochloride, LOXL2 inhibitor, PAT-1251, PAT-1251 supplier, PAT1251
CAS:
2098884-53-6
Catalog Number:
10-4976
Activity:
LOXL2 inhibitor
Chemical Names:
(R,R)-trans-(3-((4-(Aminomethyl)-6-(trifluoromethyl)pyridine-2-yl)oxy)phenyl)(3-fluoro-4-hydroxypyrrolidin-1-yl)methanone hydrochloride
Alternate Name:
Lenumlostat
Molecular Weight:
435.80
Molecular Formula:

C18H17F3N3O3·HCl

Solubility:
Soluble in DMSO (>50 mg/ml); Water (>80 mg/ml)
Physical Properties:
White solid
Purity:

>98% HPLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for up to 2 years when stored as supplied @ -20°C. Solutions in DMSO or water may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

Download Safety Data Sheet

Product Data Sheet:

Download Product Data Sheet

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

PAT-1251 (2098884-53-6) is a potent (IC50 = 710 nM) inhibitor of LOXL2, a copper-dependent amine oxidase that deaminates lysine and hydroxylysine residues in collagen and elastin. It displayed >400-fold selectivity over LOX as well as high selectivity against the related amine oxidases SSAO, DAO, and MAO-A/B.  A potential new therapeutic for the treatment of fibrotic diseases.

References/Citations:

  1. Rowbottom et al. (2017), Identification of 4-(Aminomethyl)-6-(trifluoromethyl)-2-(phenoxy)pyridine Derivatives as Potent, Selective, and Orally Efficacious Inhibitors of the Copper-Dependent Amine Oxidase, Lysyl Oxidase-Like 2 (LOXL2); J. Med. Chem. 60 4403

Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21

Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21

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