Pulmonary

Pulmonary diseases such as asthma, fibrosis, and hypertension involve inflammation, apoptosis, angiogenesis, wound healing, and many other processes. Focus Biomolecules offers many inhibitors and other modulators for the signaling pathways contributing to these, including TGF-β, Wnt, proteases, cell adhesion, AKT/mTOR, and more.

Asthma

  • Indacaterol maleate | ß2 adrenoceptor agonist/SRSF6 inhibitor
    CAS:
    753498-25-8
    Catalog Number:
    10-4371
  • Pyridone 6 | pan-JAK inhibitor
    CAS:
    457081-03-7
    Catalog Number:
    10-5555
    Activity:
    pan-JAK inhibitor
    Chemical Names:
    2-(tert-Butyl)-9-fluoro-1Hbenzo[h]imidazo[4,5-f]isoquinolin-7(6H)-one; JAK Inhibitor I
    Molecular Weight:
    309.34
    Molecular Formula:
    C18H16FN3O
    Solubility:
    Soluble in DMSO (30 mg/ml)
    Physical Properties:
    Off-white solid
    Purity:
    >98% HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • Formoterol hemifumarate | ß2 adrenergic agonist
    CAS:
    43229-80-7
    Catalog Number:
    10-5092
    Activity:
    Potent and selective β2 adrenergic agonist
    Chemical Name:
    (R,R)-N-[2-Hydroxy-5-[1-hydroxy-2-[[2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl] formamide
    Molecular Weight:
    402.44
    Molecular Formula:
    C19H24N2O4·1/2C4H4O4
    Solubility:
    Soluble in DMSO (up to 20 mg/ml)
    Physical Properties:
    White to off-white solid
    Purity:
    99% HPLC
    NMR (Conforms)
    Storage Temperature:
    Room temperature
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • N6022 | S-Nitrosoglutathione reductase inhibitor
    CAS:
    1208315-24-5
    Catalog Number:
    10-4103
    Activity:
    S-Nitrosoglutathione reductase inhibitor
    Chemical Name:
    3-(5-(4-(1H-Imidazol-1-yl)phenyl)-1-(4-carbamoyl-2-methylphenyl)-1H-pyrrol-2-yl)propanoic acid
    Molecular Weight:
    414.46
    Molecular Formula:
    C24H22N4O3
    Solubility:
    Soluble in DMSO (up to at least 25 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20° C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
    Shipping Code:
    RT
  • Pranlukast | Leukotriene CysLT1 antagonist / GPR17 antagonist
    CAS:
    103177-37-3
    Catalog Number:
    10-2441
    Activity:
    Leukotriene CysLT1 antagonist / GPR17 antagonist
    Chemical Name:
    N-[4-oxo-2-(2H-tetrazol-5-yl)chromen-8-yl]-4-(4-phenylbutoxy)benzamide
    Alternate Names:
    ONO-1078
    Molecular Weight:
    481.51
    Molecular Formula:
    C27H23N5O4
    Solubility:
    Soluble in DMSO (up to 25 mg/ml)
    Physical Properties:
    White solid
    Purity:
    98% TLC
    NMR (Conforms)
    Storage Temperature:
    -20°C
    Stability:
    Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
    Shipping Code:
    RT
View All Asthma Products

Fibrosis

View All Fibrosis Products

Other Pulmonary

  • Aldometanib | Aldolase inhibitor
    CAS:
    2904601-67-6
    Catalog Number:
    10-4445
  • Indacaterol maleate | ß2 adrenoceptor agonist/SRSF6 inhibitor
    CAS:
    753498-25-8
    Catalog Number:
    10-4371
  • UH15-38·2HCl | RIP3K inhibitor
    CAS:
    2540881-21-6 (free base)
    Catalog Number:
    10-4862
  • Formoterol hemifumarate | ß2 adrenergic agonist
    CAS:
    43229-80-7
    Catalog Number:
    10-5092
    Activity:
    Potent and selective β2 adrenergic agonist
    Chemical Name:
    (R,R)-N-[2-Hydroxy-5-[1-hydroxy-2-[[2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl] formamide
    Molecular Weight:
    402.44
    Molecular Formula:
    C19H24N2O4·1/2C4H4O4
    Solubility:
    Soluble in DMSO (up to 20 mg/ml)
    Physical Properties:
    White to off-white solid
    Purity:
    99% HPLC
    NMR (Conforms)
    Storage Temperature:
    Room temperature
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
    Shipping Code:
    RT
  • VGX-1027 | Immunomodulator; Cytokine release inhibitor
    CAS:
    6501-72-0
    Catalog Number:
    10-3409
    Activity:
    Immunomodulator; Cytokine release inhibitor
    Chemical Name:
    4,5-Dihydro-3-phenyl-5-isoxazoleacetic acid
    Alternate Name:
    GIT 27
    Molecular Weight:
    205.21
    Molecular Formula:
    C11H11NO3
    Solubility:
    Soluble in DMSO (up to 30 mg/ml).
    Physical Properties:
    White solid
    Purity:
    98% by HPLC
    NMR (Conforms)
    Storage Temperature:
    -20°
    Stability:
    Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
    Shipping Code:
    RT
View All Other Pulmonary Products