PBA | TRPM4 channel blocker

CAS:
 3128041-29-9
Catalog Number:
 10-4470
PBA chemical structure

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PBA (3128041-29-9) is a potent and selective TRPM4 channel blocker (IC50(HCT116) = 0.15 µM; IC50(HEK293) = 0.34 µM).  Active in both human and mouse.  TRPM4 blockers are of interest in treating cardiovascular diseases, neuronal diseases, and cancer

References/Citations:

  1. Gerber et al. (2026), Potent Anthranillic Anilide-Based TRPM4 Channel Inhibitors Identified by a Structure-Activity Relationship Study; J. Med. Chem. 69 8763
3128041-29-9, PBA supplier, PBA TRPM4, TRPM4 blocker, TRPM4 channel blocker, TRPM4 inhibitor
CAS:
3128041-29-9
Catalog Number:
10-4470
Activity:
TRPM4 channel blocker
Chemical Names:
4-Chloro-2-(2-(3-(prop-2-yn-1-yloxy)phenoxy)acetamido)benzoate
Molecular Weight:
359.76
Molecular Formula:

C18H14ClNO5

Solubility:
Soluble in DMSO (>100 mg/ml)
Physical Properties:
White solid
Purity:

>98% HPLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for up to 2 years when stored as supplied @ -20°C. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

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Product Data Sheet:

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Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

PBA (3128041-29-9) is a potent and selective TRPM4 channel blocker (IC50(HCT116) = 0.15 µM; IC50(HEK293) = 0.34 µM).  Active in both human and mouse.  TRPM4 blockers are of interest in treating cardiovascular diseases, neuronal diseases, and cancer

References/Citations:

  1. Gerber et al. (2026), Potent Anthranillic Anilide-Based TRPM4 Channel Inhibitors Identified by a Structure-Activity Relationship Study; J. Med. Chem. 69 8763

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