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Product Details

PBIT | JARID1 lysine demethylase inhibitor

PBIT (2514-30-9) is a potent and selective inhibitor of JARID1 (IC50 = 3, 4.9 and 6 μM for JARID1B, 1A and 1C, respectively). The JARID1 (Jumonji AT-Rich Interactive Domain 1) family of lysine demethylases demethylates the trimethylated lysine 27 in histone H3 (H3K4me3). PBIT is selective for JARID1 over UTX and JMJD3. Treatment of cells with PBIT inhibits the demethylation of H3K4me3. It inhibits proliferation of breast cancer cell lines expressing high levels of JARID1B1.

References/Citations

1) Sayegh et al. (2013), Identification of small molecule inhibitors of Jumonji AT-rich interactive domain 1B (JARID1B) histone demethylase by a sensitive high throughput screen; J. Biol. Chem., 288 9408

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PBIT | 2514-30-9 | Structure | Supplier

Catalog#  10-1595-0005

$54.00
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CAS:
2514-30-9
Catalog Number:
10-1595
Activity:
JARID1 lysine demethylase inhibitor
Chemical Name:
2-(4-Methylphenyl)-1,2-benzisothiazol-3(2H)-one
Molecular Weight:
241.31
Molecular Formula:
C14H11NOS
Solubility:
Soluble in DMSO (up to 24 mg/ml) or in Ethanol (up to 5 mg/ml)
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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