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Product Details

PBMC | TRPM8 blocker

PBMC is a potent and selective inhibitor of TRPM8 channels. PBMC inhibits both chemical and thermal activation of TRPM8.1 Reverses the menthol and cold-induced facilitation of the micturition reflex.2 PBMC represents a new lead for analgesic drugs based on blocking TRPM8.3

References/Citations
1) Knowlton et al. (2011), Pharmacological blockade of TRPM8 ion channels alters cold and cold pain responses in mice; PLoS One, 6(9) e25894
2) Gardiner et al. (2014), The role of TRPM8 in the Guinea-pig bladder-cooling reflex investigated using a novel TRPM8 antagonist; Eur. J. Pharmacol., 740 398
3) Salat et al. (2013), Transient receptor potential channels - emerging novel drug targets for the treatment of pain; Curr. Med. Chem., 20 1409

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PBMC | Structure | Supplier

Catalog#  10-1413

$70.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
Not Available
Catalog Number:
10-1413
Activity:
TRPM8 blocker
Chemical Name:
(S)-1-Phenylethyl(2-aminoethyl)(4-(benzyloxy)-3-methoxybenzyl)carbamate
Molecular Weight:
434.54
Molecular Formula:
C26H30N2O4
Solubility:
Soluble in DMSO (up to 30 mg/ml).
Physical Properties:
Light brown oil
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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